(HealthDay News) -- U.S. scientists say they've identified key gene variants tied to an increased risk of testicular cancer.
They said the findings are an important step toward understanding which men are at high risk for the disease.
"Despite being quite heritable, there really have not been any clear genetic risk factors that can account for most cases of testicular cancer. These variants are the first striking genetic risk factors found for this disease to date," Dr. Katherine L. Nathanson, an assistant professor of medicine at the University of Pennsylvania School of Medicine and a specialist in medical genetics at the Abramson Cancer Center, said in a news release.
Nathanson and colleagues found that men with two copies of the common version of the c-KIT ligand (KITLG) gene are 4.5 times more likely to develop testicular cancer than men with two copies of the less common versions of the gene. Read more...
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